TAL1

Proteína 1 de leucemia linfoide aguda de células T
HUGO	11556
Símbolo	TAL1
Símbolos alt.	SCL, TCL5, tal-1
Datos genéticos
Locus	Cr. 1 p33
Bases de datos
Entrez	6886
OMIM	187040
RefSeq	NP_003180
UniProt	P17542

La proteína 1 de leucemia linfoide aguda de células T es una proteína codificada en humanos por el gen tal1.^{[1] [2]} TAL1 es un factor de transcripción con un dominio hélice-bucle-hélice implicada, cuando está truncada o ausente, en el desarrollo de leucemia linfoide aguda de células T.

Interacciones

La proteína TAL1 ha demostrado ser capaz de interaccionar con:

• LMO1^{[3] [4]}
• LDB1^[5]
• SIN3A^[6]
• LMO2^{[4] [3] [5] [7]}
• Sp1^[8]
• TCF3^{[5] [9]}
• CBFA2T3^[5]
• EP300^[10]
• GATA1^{[5] [7]}

Referencias

1. ↑ Finger LR, Kagan J, Christopher G, Kurtzberg J, Hershfield MS, Nowell PC, Croce CM (Aug 1989). «Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma». Proc Natl Acad Sci U S A 86 (13):  pp. 5039–43. PMID 2740341. 
2. ↑ «Entrez Gene: TAL1 T-cell acute lymphocytic leukemia 1».
3. ↑ ^{a b} Valge-Archer, V E; Osada H, Warren A J, Forster A, Li J, Baer R, Rabbitts T H (Aug. 1994). «The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (18):  pp. 8617–21. ISSN 0027-8424. PMID 8078932. 
4. ↑ ^{a b} Wadman, I; Li J, Bash R O, Forster A, Osada H, Rabbitts T H, Baer R (Oct. 1994). «Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia». EMBO J. (ENGLAND) 13 (20):  pp. 4831–9. ISSN 0261-4189. PMID 7957052. 
5. ↑ ^{a b c d e} Goardon, Nicolas; Lambert Julie A, Rodriguez Patrick, Nissaire Philippe, Herblot Sabine, Thibault Pierre, Dumenil Dominique, Strouboulis John, Romeo Paul-Henri, Hoang Trang (Jan. 2006). «ETO2 coordinates cellular proliferation and differentiation during erythropoiesis». EMBO J. (England) 25 (2):  pp. 357–66. doi:10.1038/sj.emboj.7600934. ISSN 0261-4189. PMID 16407974. 
6. ↑ Huang, S; Brandt S J (Mar. 2000). «mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or SCL) transcription factor». Mol. Cell. Biol. (UNITED STATES) 20 (6):  pp. 2248–59. ISSN 0270-7306. PMID 10688671. 
7. ↑ ^{a b} Osada, H; Grutz G, Axelson H, Forster A, Rabbitts T H (Oct. 1995). «Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (21):  pp. 9585–9. ISSN 0027-8424. PMID 7568177. 
8. ↑ Lécuyer, Eric; Herblot Sabine, Saint-Denis Marianne, Martin Richard, Begley C Glenn, Porcher Catherine, Orkin Stuart H, Hoang Trang (Oct. 2002). «The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1». Blood (United States) 100 (7):  pp. 2430–40. doi:10.1182/blood-2002-02-0568. ISSN 0006-4971. PMID 12239153. 
9. ↑ Hsu, H L; Wadman I, Baer R (Apr. 1994). «Formation of in vivo complexes between the TAL1 and E2A polypeptides of leukemic T cells». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 91 (8):  pp. 3181–5. ISSN 0027-8424. PMID 8159721. 
10. ↑ Huang, S; Qiu Y, Stein R W, Brandt S J (Sep. 1999). «p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein». Oncogene (ENGLAND) 18 (35):  pp. 4958–67. doi:10.1038/sj.onc.1202889. ISSN 0950-9232. PMID 10490830. 

Enlaces externos

• MeSH TAL1+protein,+human